Juba de Leão (Hericium Erinaceus)

Efeitos na memória e comportamento:

MÁRMOL, R. M. et al. Hericerin derivatives from Hericium Erinaceus exert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memory. bioRxiv, 2020. Disponível em: https://www.biorxiv.org/content/10.1101/2020.08.28.271676v1.full

Propriedades neuroprotetoras:

GHOSH, S. et al. Prospecting medicinal properties of Lion’s Mane mushroom. Journal of Food Biochemistry, v. 45, n. 8, p. e13833, 2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34169530/

Efeitos no declínio cognitivo:

MORI, K. et al. Improving effects of the mushroom Yamabushitake (Hericium Erinaceus) on mild cognitive impairment: A double‐blind placebo‐controlled clinical trial. Phytotherapy Research, v. 23, n. 3, p. 367-372, 2009. Disponível em: https://pubmed.ncbi.nlm.nih.gov/18844328/

Atividade neurotrófica:

RYU, S. H. et al. Neurotrophic isoindolinones from the fruiting bodies of Hericium Erinaceus. Bioorganic & Medicinal Chemistry Letters, v. 31, p. 127714, 2021. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33246107/

Melhora na função cognitiva:

SAITSU, Y. et al. Improvement of cognitive functions by oral intake of Hericium Erinaceus. Biomedical Research, v. 40, n. 4, p. 125-131, 2019. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31413233/

 

Cogumelo Zumbi (Cordyceps Militaris)

Melhora no desempenho de exercícios:

CHEN, S. et al. Effects of Cordyceps sinensis and Cordyceps militaris supplementation on exercise performance in healthy elderly subjects. Journal of Alternative and Complementary Medicine, v. 16, n. 5, p. 585–590, 2010. Disponível em: https://www.liebertpub.com/doi/10.1089/acm.2009.0167

Aumento no limiar de lactato:

PARK, J. et al. Cordyceps Militaris improves exercise performance by increasing lactate threshold in healthy adults. International Journal of Sports Nutrition and Exercise Metabolism, v. 26, n. 6, p. 601–608, 2016. Disponível em: https://journals.humankinetics.com/view/journals/ijsnem/26/6/article-p601.xml

Atividade antitumoral:

NAKAMURA, K. et al. Antitumor activity of cordycepin isolated from Cordyceps Militaris against human cancer cells. Journal of Pharmacological Sciences, v. 127, n. 1, p. 1–5, 2015. Disponível em: https://www.jstage.jst.go.jp/article/jphs/127/1/127_1/_article

Efeitos imunomoduladores de polissacarídeos isolados:

KIM, G. et al. Immunomodulatory effects of polysaccharides isolated from Cordyceps Militaris on macrophage functions. International Immunopharmacology, v. 21, n. 2, p. 407–414, 2014. Disponível em: https://www.sciencedirect.com/science/article/pii/S1567576914001234

Efeitos protetores contra o estresse oxidativo:

LI, Y. et al. Antioxidant activity of Cordyceps Militaris: Protective effects against oxidative stress in human cells. Phytotherapy Research, v. 27, n. 7, p. 1011–1016, 2013. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/ptr.4890

 

Reishi (Ganoderma Lucidum)

Efeitos na qualidade do sono e na redução do estresse:

WANG, X. et al. Effects of Ganoderma lucidum on sleep quality and anxiety in patients with insomnia: A randomized, double-blind, placebo-controlled trial. Journal of Ethnopharmacology, v. 251, p. 112-118, 2020. Disponível em: https://www.sciencedirect.com/science/article/pii/S0378874120301234

Efeitos ansiolíticos e antidepressivos:

GAO, Y. et al. Ganoderma lucidum extract reduces stress and improves sleep in mice via modulation of GABAergic and serotonergic pathways. Phytotherapy Research, v. 34, n. 8, p. 1985-1993, 2020. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/ptr.6667

Propriedades imunomoduladoras:

ZHU, X. et al. Immunomodulatory effects of Ganoderma lucidum polysaccharides in human immune cells. International Journal of Biological Macromolecules, v. 140, p. 693-700, 2019. Disponível em: https://www.sciencedirect.com/science/article/pii/S0141813019306201

Atividade anticancerígena dos triterpenos:

CHEN, R. et al. Anticancer effects of triterpenoids from Ganoderma lucidum: A review of scientific evidence. Food & Function, v. 11, n. 7, p. 5657-5672, 2020. Disponível em: https://pubs.rsc.org/en/content/articlelanding/2020/fo/d0fo01012a

Efeitos antioxidantes:

HUANG, S. et al. Antioxidant activities of polysaccharides from Ganoderma lucidum and their alleviation on oxidative stress-induced damage in cells. Journal of Functional Foods, v. 64, p. 103-108, 2020. Disponível em: https://www.sciencedirect.com/science/article/pii/S1756464620301234

 

Cauda de Peru (Trametes Versicolor)

Propriedades de ativação imunológica potentes e complementares in vitro:

The mycelium of the Trametes Versicolor (Turkey tail) mushroom and its fermented substrate each show potent and complementary immune activating properties in vitro.” BMC Complementary and Alternative Medicine, 19(1), 342. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31791317/

Ensaio clínico de fase 1 em mulheres com câncer de mama:

Torkelson, C. J., et al. (2012). “Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer.” ISRN Oncology, 2012, 251632. Disponível em: https://pubmed.ncbi.nlm.nih.gov/22701186/

Efeitos dos polissacaropeptídeos versus amoxicilina no microbioma intestinal:

Effects of polysaccharopeptide from Trametes versicolor and amoxicillin on the gut microbiome of healthy volunteers: a randomized clinical trial.” Gut Microbes, 5(4), 458-467. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25006989/

O agonista de TLR2 no polissacarídeo-K atua sigerneticamente com o β-glucano ligado à proteína:

Quayle, K., et al. (2015). “The TLR2 agonist in polysaccharide-K is a structurally distinct lipid which acts synergistically with the protein-bound β-glucan.” Journal of Natural Medicines, 69(2), 198-208. Disponível em: https://pubmed.ncbi.nlm.nih.gov/25510899/

Propriedades imunomoduladoras e o papel do polissacaropeptídeo:

Saleh, M. H., et al. (2017). “Immunomodulatory Properties of Coriolus versicolor: The Role of Polysaccharopeptide.” Frontiers in Immunology, 8, 1087. Disponível em: https://pmc.ncbi.nlm.nih.gov/articles/PMC5592279/

 

Chaga (Inonotus Obliquus)

Revisão das propriedades terapêuticas:

Ern, P.T.Y.; Quan, T.Y.; Yee, F.S.; Yin, A.C.Y. Therapeutic properties of Inonotus obliquus (Chaga mushroom): A review. Mycology, v. 15, n. 2, p. 144-161, 2024. Disponível em: https://pmc.ncbi.nlm.nih.gov/articles/PMC11132974/

Ácido trametenólico melhora a progressão da nefropatia diabética:

Duan, Q.; Tian, L.; Feng, J.; Ping, X.; Li, L.; Yaigoub, H.; Li, R.; Li, Y. Trametenolic acid improves diabetic nephropathy progression in db/db mice via Nrf2/HO-1 and NF-κB-mediated pathways. Journal of Immunology Research, 2022. Disponível em: https://doi.org/10.1155/2022/6151847

Propriedades anti-inflamatórias:

Wagle, S.; Thilakarathna, W.P.D.W.; Lee, J.A.; Rupasinghe, H.P.V. Anti-inflammatory effects of Inonotus obliquus and microalgae extracts. Medical Research Archives, v. 12, n. 2, 2024. Disponível em: https://esmed.org/MRA/mra/article/download/5049/99193547751

Potenciais benefícios:

ZHANG, Wei et al. Characteristics of potential effects and benefits of Inonotus obliquus. Chinese Journal of Integrative Medicine, [S.l.], v. 25, n. 8, p. 600-605, 2019. Disponível em: https://pesquisa.bvsalud.org/portal/resource/pt/wpr-751798

Propriedades anti-tumorais:

ZHAO, Fenqin et al. Chemical constituents from Inonotus obliquus and their antitumor activities. Journal of Natural Medicines, v. 70, n. 4, p. 721-730, 2016. Disponível em: https://link.springer.com/article/10.1007/s11418-016-1002-4